External factors
| External factors: |
Gomisin A |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
The aged HDF cells (PD61) showed markedly higher levels of SA-β-gal activity than the middle passage cells,while gomisin A significantly reduced aging induced SA-β-gal activity. |
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Regulatory relationship
| Regulatory pathway:
|
MAPK-NF-κB |
| R-EF-Pathway:
|
Downregulation |
| Official symbol(s): |
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MAPK
|
| Pathway experiment: |
Western blot |
| Pathway description: |
The SIPS-HDF cells activated MAPK signaling including p-ERK, p-p38, and p-JNK, but gomisin A inhibited the SIPS-induced MAPKs. Furthermore, gomisin A blocked the NF-κB translocation from the cytosol to the nucleus. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.