External factors
| External factors: |
Extracellular vesicles |
| Experiment: |
SA-β-gal activity assay |
| Description: |
DOX greatly increased βgal positive cells, which was significantly ameliorated by human serum EVs treatment. |
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Regulatory relationship
| Regulatory pathway:
|
miR-34a-PNUTS |
| Official symbol(s): |
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MIR34A-PPP1R10
|
| Pathway description: |
In H9C2 cells, we found that EVs significantly decreased the expression level of miR-34a.Our study also found that miR-34a mimic downregulated PNUTS expression in H9C2 cells, while miR-34a inhibitor significantly elevated that. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.