External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
R1-C mice showed a few SA-beta-GAL-positive cells,whereas the R1-T and P8-C groups had more cells showing prominent SA-beta-GAL staining. As expected, the P8-T group had the most cells showing robust SA-beta-GAL staining among all groups. |
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Regulatory relationship
| R-EF-Pathway:
|
Downregulation |
| Official symbol(s): |
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MTOR
|
| Pathway experiment: |
Western blot//qRT-PCR |
| Pathway description: |
The phosphorylation levels of mTOR, p70s6k and 4EBP2 were significantly decreased in P8-C compared with R1-C.These proteins were decreased significantly in the TMAO groups compared to the control groups, especially in P8-T. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.