External factors
| External factors: |
Autophagy |
| Experiment: |
SA-β-gal activity assay//Western blot |
| Description: |
3-MA and LY also inhibited CDKN1A and CDKN2A upregulation as well as SA-GLB1/β-gal activity in serum-starved fibroblasts. |
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Regulatory relationship
| Regulatory pathway:
|
MTORC2 |
| Official symbol(s): |
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ARMH4
|
| Pathway experiment: |
SA-β-gal activity assay//Western blot |
| Pathway description: |
Serum-starved fibroblasts exposed to R showed lowered CDNK1A and CDKN2A protein levels and decreased SA-GLB1/β-gal activity .RPTOR silencing led, however, to inhibition of SA-GLB1/β-gal activity. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Pathway view
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