External factors
| Category: |
Chemical compounds |
| Phenotype: |
Age-related macular degeneration |
| Experimental category: |
HL |
| Experiment: |
SA-β-gal activity assay//qRT-PCR |
| Description: |
Our results showed that A2E treatment triggered cellular senescence, an effect that was intensified by blue light;We measured telomere length (T/S ratio) using RT-qPCR and found that photosensitization of A2E induced significant telomere erosion, which could be decreased by NAC. |
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Regulatory relationship
| Regulatory pathway:
|
NF-κB |
| Official symbol(s): |
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NFKB1
|
| Pathway experiment: |
Gene Ontology assay |
| Pathway description: |
GO analysis of the upregulated genes also showed a significant enrichment (p <0.05) for 38 GO terms, including“positive regulation of NF-kappa B transcription factor activity”.These findings suggest that the NF-κB pathway is activated upon photosensitization of A2E in RPE cells. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.