External factors
| Phenotype: |
Cardiovascular disease |
| Tissue type: |
Mice endothelium tissue |
| Experiment: |
SA-β-gal activity assay//Western blot |
| Description: |
In accordance with expectations,the HFD group showed a significant elevation in SA β-gal-positive areas of the endothelium (stained as blue) in comparison with the vehicle control group.A faint staining pattern of SMP30 was found in the endothelium (marked by CD-31) of the aortic roots in mice fed with HFD. |
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Regulatory relationship
| Regulatory pathway:
|
NLRP3 |
| R-EF-Pathway:
|
Upregulation |
| Official symbol(s): |
Warning: Undefined variable $name_all in /data/html/Aging-ReG/public/browse_detail_2.php on line 525
NLRP3
|
| Pathway experiment: |
Western blot |
| Pathway description: |
The results of western blot analysis showed that D-gal significantly increased the expression of NLRP3 in HUVECs as compared with that of vehicle control. On the contrary, PSPC administration depressed the amplification of NLRP3 induced by D-gal. A similar pattern of NLRP3 was observed for the immunofluorescence activities in the brachiocephalic artery of mice which were fed with HFD or HFD+PSPC . |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.