External factors
| External factors: |
Doxorubicin |
| Category: |
Chemical compounds |
| Phenotype: |
Nijmegen Breakage Syndrome |
| Experiment: |
SA-β-gal activity assay |
| Description: |
We observed a time-dependent increase in the number of SA-β-Gal positive cells in L5 and S4, but not in S3R cell line. |
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Regulatory relationship
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| Regulatory pathway:
|
p16-pRb//p53-p21 |
| R-EF-Pathway:
|
Downregulation//Activation |
| Pathway experiment: |
Western blot |
| Pathway description: |
We did not observe any changes in the level of this protein in the S3R and S4 cell lines, however, a time dependent decrease in the level of p16 was observed in the L5 cell line.In the L5 and S4 cells stronger activation of the p53/ p21 pathway correlated with an increase in SA-β-Gal activity. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Pathway view
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