External factors
| External factors: |
4-(4-fluorophenyl)-2-phenyl-5,6,7,8-tetrahydroquinoline |
| Category: |
Chemical compounds |
| Phenotype: |
Ovarian cancer |
| Experiment: |
SA-β-gal activity assay//Western blot |
| Description: |
FPTHQ treatment dramatically increased the number of SA - β -gal positive A2780 cells.FPTHQ -treatment increased the protein levels of MMP3 and the mRNA levels of IL-6 and IL-8 in A2780 cells. |
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Regulatory relationship
| R-EF-Pathway:
|
Upregulation |
| Official symbol(s): |
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CDKN1A
|
| Pathway experiment: |
SA-β-gal activity assay//Western blot |
| Pathway description: |
In addition, we found that p21 was significantly up -regulated after FPTHQ treatment.Consistent with the observations in other two cell lines, FPTHQ also significantly increased the protein level of p21 in SKOV -3 cells. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.