External factors
| External factors: |
Surfactant |
| Cell name: |
TIG-7,CK,BK,FDPC |
| Experiment: |
SA-β-gal activity assay//Cell morphological analysis |
| Description: |
Various cell types were cultured in the presence of sublethal concentrations of genuine surfactants (NP-40, Triton X-100, SDS, Tween 20, etc) and commercially available products (dishwasher, shampoo, or facial cleansing foam) for 12 weeks. Normal type of cells examined, namely normal human fibroblasts (TIG-7), CK, BK, and FDPC, and all exhibited typical senescence features, flat and enlarged cell shape, and were clearly stained with the senescence-associated β-galactosidase. |
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Regulatory relationship
| Official symbol(s): |
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MAPK14
|
| Pathway experiment: |
SA-β-gal activity assay |
| Pathway description: |
Among the above inhibitors, only p38 inhibitor SB203580 clearly suppressed the senescence induced by NP-40. It suppressed the senescence induced by oleic acid or SDS as well as NP-40. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.