External factors
| External factors: |
DmHsp22 |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
We found significant lower level of β-galactosidase expression in DmHsp22-expressing cells .Control cells entered senescence at 45 PD, as marked by their morphology and slow growth, the DmHsp22-expressing cells showed younger morphology and continued dividing until~5 PD . |
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Regulatory relationship
| R-EF-Pathway:
|
Downregulation |
| Official symbol(s): |
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TP53
|
| Pathway experiment: |
Western blot//Immunostaining |
| Pathway description: |
The intensity of nuclear p53 staining in DmHsp22-expressing cells was lower as compared with the control cells. Furthermore, inDmHsp22-expressing U2OS cells, we found that there was a significant decrease in DNA damage-induced activation of p53 pathway. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.