External factors
| External factors: |
Nutlin-3 |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Cell Cycle analysis |
| Description: |
All cells stained intensely for SA-β-Gal activity .Bromodeoxyuridine (BrdU) labeling revealed that less than 1% of the cell population is in S phase, indicating that they have exited the cell cycle . |
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Regulatory relationship
| Official symbol(s): |
Warning: Undefined variable $name_all in /data/html/Aging-ReG/public/browse_detail_2.php on line 525
TP53
|
| Pathway experiment: |
Western blot |
| Pathway description: |
Treatment of early passage and senescent WI-38 cells with 10 μM nutlin-3a for 24 hours elevated p53 protein in both senescent and early passage cells . |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.