External factors
| External factors: |
Ginsenoside Rg3 |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
~67% of U87 cells after chronic 20(S)-Rg3 treatment at a 20 M concentration were stained positively compared with only ~5% cells with positive staining in the DMSO control group. |
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Regulatory relationship
| Regulatory pathway:
|
p53-p21//Akt |
| R-EF-Pathway:
|
Upregulation//Activation |
| Official symbol(s): |
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TP53-CDKN1A//AKT1
|
| Pathway experiment: |
Western blot |
| Pathway description: |
The treatment of U87 cells with 20(S)-Rg3 significantly increased the expression levels of p53 and p21.U87 cells treated with 20 M 20(S)-Rg3 were characterized by increases in phosphoAkt. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.