External factors
| External factors: |
17β-Estradiol |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Co-incubation with 17b-estradiol significantly inhibited the increase in SA-β-gal-positive cells.17b-estradiol dose-dependently increased telomerase activity. |
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Regulatory relationship
| Regulatory pathway:
|
PI3K-Akt |
| Official symbol(s): |
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PIK3CB-AKT
|
| Pathway experiment: |
Western blot |
| Pathway description: |
Interestingly, pretreatment with phosphatidylinositol 3-kinase (PI3-K) blockers,either wortmannin or LY294002, significantly attenuated the increase inhTERT mRNA induced by 17β-estradiol.We examined the effect of 17β-estradiol on Akt activity in EPCs. EPCs were stimulated with several different doses of 17β-estradiol for 1 h and immunoblots were performed with a phosphospecific Akt antibody directed at the Ser473 phosphorylation site. Stimulation with 17β-estradiol led to a dose-dependent phosphorylation of Akt. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.