External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
SA-β-gal activity significantly(p＜0.05) enhanced in H2O2treated cells with over 60% cells appearing senescent as compared to control group, which was significantly (p＜0.05) abrogated on treatment with EGCG. |
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Regulatory relationship
| Regulatory pathway:
|
PI3K-Akt-mTOR |
| R-EF-Pathway:
|
Downregulation |
| Official symbol(s): |
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PI3K-AKT-MTOR
|
| Pathway experiment: |
Western blot |
| Pathway description: |
EGCG treatment significantly (p＜0.05) downregulated expression of both PI3K and Akt as well as p-mTOR(albeit at 100 lM only) suggesting its role in modulation of stress-induced mTOR signaling pathway. A suppression in the gene expression of translation initiation factors (4E-BP1 and eIF4E) downstream of mTOR pathway was also observed that further indicated the inactivation of mTOR pathway in the presence of EGCG. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.