External factors
| External factors: |
Cardiac glycoside |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
The number of SA-β-Gal positive cells increased after the treatment of all cardiac glycosides for 72 h, significantly indicating the cardiac glycoside-induced senescence in HeLa cells. |
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Regulatory relationship
| Regulatory pathway:
|
Rho-Rho |
| Official symbol(s): |
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rhodopsin
|
| Pathway experiment: |
Cell morphological analysis |
| Pathway description: |
The measurements demonstrated that cardiac glycosides increased the cell areas in HeLa cells comparing to the control group. Pretreatment of Rock inhibitor, Y-27632, significantly reduced the increased cell area induced by cardiac glycosides. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Pathway view
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