External factors
| External factors: |
Resveratrol |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
In accordance to these changes, RSV or MET treatment also significantly increased the expression of SMP-30 and decreased the percentage of SA β-Gal staining in HN-treated HUVECs. |
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Regulatory relationship
| Regulatory pathway:
|
SIRT1 |
| R-EF-Pathway:
|
Upregulation |
| Official symbol(s): |
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SIRT1
|
| Pathway experiment: |
Western blot |
| Pathway description: |
When cells were treated with RSV or MET during the incubation in HG for 3 days followed by NG for another 3 days, the expression and deacetylase activity of SIRT1 were significantly increased and the expression of p300, Ac-p53, and p21 was significantly decreased . |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.