External factors
| External factors: |
Melatonin |
| Category: |
Chemical compounds |
| Experiment: |
Histological staining |
| Description: |
In control mice not treated and treated with FAST or RETARD melatonin and in APOE-treated mice with both formulations of melatonin,the vessels showed a normal morphology. |
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Regulatory relationship
| Regulatory pathway:
|
SIRT1-p53-eNOS |
| Official symbol(s): |
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SIRT1-TP53-NOS3
|
| Pathway experiment: |
Immunostaining |
| Pathway description: |
SIRT1 was expressed in cytoplasm and nuclei of tunica intima cells of APOE FAST-and RETARD-treated mice.On the contrary, intima, media, and adventitial cells were negative in the vessels of control mice and in those given either APOE FAST or RETARD melatonin .Melatonin treatments restored significantly the expression of this protein after either in APOE FAST or RETARD melatonin treatment. This positivity was moderate in ECs of APOE FAST-treated animals and strong in APOE RETARD-treated mice. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.