External factors
| External factors: |
Ultraviolet radiation |
| Experimental category: |
HL |
| Experiment: |
SA-β-gal activity assay |
| Description: |
When cells were exposed to UVA (7.5 J/cm2) or UVB (0.25 J/cm2) for 24 h, S HDFs showed an increased number of SA-β-gal positive cells as compared to control-treated cells, whereas NS HDFs showed negative staining for SA-β-gal activity. |
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Regulatory relationship
| Regulatory pathway:
|
TLR4-ERK |
| Official symbol(s): |
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TLR4-MAPK1
|
| Pathway experiment: |
Mitochondrial flux analysis |
| Pathway description: |
Furthermore, ERK or TLR4 inhibitor-treated senescent HDFs had strikingly decreased OCR than control-treated cells, suggesting that TLR4-ERK signaling pathways can lead to control of mitochondrial metabolic profilings in senescent HDFs. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.