External factors
| External factors: |
Norcantharidin |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
SA-β-Gal assay showing that NCTD at 15 μM significantly increased cell senescence phenotype in A549 cells for 72 h. |
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Regulatory relationship
| R-EF-Pathway:
|
Downregulation |
| Official symbol(s): |
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YAP1
|
| Pathway experiment: |
RT-PCR//Western blot |
| Pathway description: |
NCTD time-dependently reduced Yap mRNA(E) and protein level (F) in A549 cells at 15 μΜ. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.