External factors
| External factors: |
Drug abuse |
| Experiment: |
SA-β-gal activity assay//Cell morphological analysis//Western blot |
| Description: |
Meth significantly induced SA-β-Gal expression even at the lower meth dose of 10 lM ；Meth-treated HFAs demonstrated a classical flat morphology of senescent astrocytes ;Meth also increased the expression of another marker of cell senescence, p161NK4A, as evaluated by Meth also increased the expression of another marker of cell senescence, p161NK4A, as evaluated by Western blot. |
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Regulatory relationship
| Regulatory pathway:
|
β-catenin |
| R-EF-Pathway:
|
Downregulation |
| Official symbol(s): |
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CTNNBIP1
|
| Pathway experiment: |
SA-β-gal activity assay |
| Pathway description: |
Meth at 300 lM inhibited TOPflash activities by approximately 45%. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.