External factors
| External factors: |
12-O-tetradecanoylphorbol-13-acetate |
| Category: |
Chemical compounds |
| Experimental category: |
HL |
| Experiment: |
RNA-seq//Cell morphological analysis |
| Description: |
All data strongly supported the occurrence of cell cycle progression, along with the morphological and cytoskeletal changes in senescent cells linked with reduced focal adhesion to extracellular matrix. |
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Regulatory relationship
| Target gene:
|
PKCα//PERK1/2 |
| R-EF-Target gene:
|
Downregulation//-- |
| Official symbol(s): |
PRKCA//MAPK1 |
| Target gene experiment: |
Knockdown//Immunocytochemistry |
| Target gene description: |
Indeed, the knockdown of PKCα expression significantly reduced pErk1/2 translocation after TPA treatment.The loss of PKCα expression was much faster after TPA treatment than after siPKCα transfection. |
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Aging network
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Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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