External factors
| External factors: |
Gamma irradiation |
| Cell name: |
MSC,Fibroblast |
| Experiment: |
SA-β-gal activity assay//Flow cytometry |
| Description: |
We observed a dose-dependent decrease in proliferation that leveled around 5Gy.SABG activity was detected in damaged MSC or fibroblasts 9 days following irradiation while no detectable SABG expression was found baseline (0 Gy). This was confirmed by a significant increase in cell size 8 days after irradiation as measured by flow cytometry.Overall, irradiated MSC display all the critical hallmarks associated with the presence of a senescence-associated persistent DDR. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Target gene experiment: |
Immunoflurescence |
| Target gene description: |
Immunoflurescence targeting PML revealed a strong increase of the protein in MSC, 10 days after 5Gy irradiation. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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