External factors
| External factors: |
Tamoxifen |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
SA-β-gal staining in both MCF-7 and HCT116 cells increased with tamoxifen treatment. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
CSNK2A1 |
| Target gene experiment: |
Western blot |
| Target gene description: |
Endogenous CK2 activity was reduced in MCF-7 and HCT116 cells treated with tamoxifen. |
| Regulatory pathway:
|
p53-p21 |
| R-EF-Pathway:
|
Upregulation |
| Official symbol(s): |
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TP53-CDKN1A
|
| Pathway experiment: |
Western blot |
| Pathway description: |
Immunoblotting showed that the protein levels of p53 and p21Cip1/WAF1 were up-regulated in tamoxifen-treated cells. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.