External factors
| Experiment: |
SA-β-gal activity assay//Cell morphological analysis//ELISA//qRT-PCR |
| Description: |
After 2 weeks, PUVA HDFs showed the typical enlarged and flattened senescent-like morphology and displayed de novo expression of SA-β-gal showing an expression fourfold higher than the control cells.Two weeks after PUVA,we observed a relevant decrease in type I pro-collagen expression and a significant increase in the release of MMP-1. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
PPARG |
| Target gene experiment: |
Luciferase reporter assay |
| Target gene description: |
PUVA exposure decreased luciferase expression of PPARγ at 24 and 48 h. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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