External factors
| External factors: |
Azelaic acid |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Cell morphological analysis//qRT-PCR//ELISA |
| Description: |
AzA partly counteracted the cell shape change,AzA treatment after PUVA significantly reduced the SA-β-gal staining intensity .Supplementation with AzA significantly decreased MMP-1 protein concentrations and counteracted the PUVA-induced downmodulation of type I pro-collag. |
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Regulatory relationship
| R-EF-Target gene:
|
Activation |
| Official symbol(s): |
PPARG |
| Target gene experiment: |
Luciferase reporter assay |
| Target gene description: |
Our results showed a significant induction of the PPAR-γctranscriptional activity after 24 and 48 h of AzA treatment. Interestingly, PUVA exposure decreased luciferase expression at 24 and 48 h, and AzA 2.5 mM partially counteracted this effect. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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