External factors
| External factors: |
Melatonin |
| Category: |
Chemical compounds |
| Phenotype: |
Chronic kidney disease |
| Experiment: |
SA-β-gal activity assay//Western blot |
| Description: |
Melatonin pretreatment restored cellular morphology of H2o2 -enlarged cells , with 100 μM melatonin most effectively reducing cell size. In addition, 100 μM melatonin -treated CKD -mMSCs showed a substantial reduction in the number of β-gal -positive cells. Furthermore,melatonin significantly downregulated p -P53 and p16INK4A, upregulated SMP30 reduced by H2O2 , and significantly downregulated P21. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Target gene experiment: |
Western blot |
| Target gene description: |
CKD -MCSs treated with H2O2 exhibited decreased PrPC , whereas melatonin pretreatment significantly upregulated PrPC. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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