External factors
| External factors: |
Mussel oligopeptides |
| Experiment: |
MTT assay//Flow cytometry//Cell morphological analysis//SA-β-gal activity assay//SAHF |
| Description: |
Compared with PSC, mussel oligopeptidestreated cells showed a significant dose-dependent increase in cell viability.In H2O2treated cells,pretreatment with mussel oligopeptides resulted in a significant decrease of cells in G0/G1phase (from 69.9% to 31.5%) (P < 0.05)and a concomitant increase of cells in S phase (from 27.5% to 49.1%) and G2/M phase (from 2.6% to 18.3%) (P < 0.01).When cells were pretreated with mussel oligopeptides, a significant decrease in SA-β-gal activity was observed compared with the PSC cells. |
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Regulatory relationship
| Target gene:
|
PRX1//NAMPT//SIRT1 |
| R-EF-Target gene:
|
Upregulation//Upregulation//Upregulation |
| Official symbol(s): |
PRX1//NAMPT//SIRT1 |
| Target gene experiment: |
qRT-PCR |
| Target gene description: |
Treatment with mussel oligopeptides significantly increased the H2O2-triggered expression of Prx1, SIRT1 and NAMPT. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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