External factors
| External factors: |
Melatonin |
| Category: |
Chemical compounds |
| Phenotype: |
Systemic lupus erythematosus |
| Tissue type: |
Umbilical cord |
| Experiment: |
SA-β-gal activity assay//Western blot//BrdU assay |
| Description: |
Senescent cells were decreased in the melatonin-treated group.P53 and P21 were downregulated whereas Cyclin D1, CDK4, and CDK6 were upregulatedwhen cells were cultured with melatonin.Ten μM melatonin increased HUVEC proliferation in SLE medium. |
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Regulatory relationship
| R-EF-Target gene:
|
Activation |
| Target gene experiment: |
Knockdown//SA-β-gal activity assay//Western blot//BrdU assay |
| Target gene description: |
RORα-knockdown increased the percentage of senescent HUVECs, although cells were treated with melatonin. P53 and P21 were increased whereas Cyclin D1, CDK4, and CDK6 were decreased when RORα was silenced in HUVECs, although cells were protected with melatonin.However, in the RORα-silenced group, HUVEC proliferation was inhibited, although cells were treated with melatonin. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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