External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Western blot |
| Description: |
Elevating levels of aging proteins P53 and P16 were shown in myeloma cell line RPMI8226 after being induced by H2O2. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
DUSP5 |
| Target gene experiment: |
Western blot |
| Target gene description: |
We further observed that in H2O2 -induced myeloma cell line RPMI8226 aging model, DUSP level was apparently increased, suggesting the possible relation of DUSP to H2O2 -induced myeloma cell aging. |
| R-EF-Pathway:
|
Downregulation |
| Official symbol(s): |
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TLR4
|
| Pathway experiment: |
Western blot |
| Pathway description: |
Also, the remarkable reduction of TLR4 was involved in myeloma cell aging model compared to normal control . |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.