External factors
| External factors: |
OVX surgery |
| Experiment: |
SA-β-gal activity assay//Western blot |
| Description: |
The ratio of arterial senescence,assessed by SA-β gal,was greater in OVX mice than in sham mice.Western blot analysis revealed that the arterial expression of SIRT1 protein and the ratio of p-eNOS to eNOS were lower in OVX mice than in sham mice and the expression of Ac-p53, p21, p16, and PAI-1 was higher in OVX mice than in sham mice . |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
SIRT1 |
| Target gene experiment: |
Western blot |
| Target gene description: |
Western blot analysis revealed that the arterial expression of SIRT1 protein and the ratio of p-eNOS to eNOS were lower in OVX mice than in sham mice and the expression of Ac-p53, p21, p16, and PAI-1 was higher in OVX mice than in sham mice. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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