External factors
| External factors: |
X-radiation |
| Description: |
Consistent with previous reports,the hTERT-mediated immortalized MRC-5 (MRC-5/TERT) and BJ (BJ/TERT) cell lines underwent senescence and the induction of IL-8 mRNA was also observed upon x-radiation. The expression of IL-8 and IL-6 mRNAs and proteins was increased after the induction of senescence. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
SIRT1 |
| Target gene experiment: |
Western blot |
| Target gene description: |
In contrast, expression of the SIRT1 protein was decreased 3 days after the induction of senescence. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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