External factors
| External factors: |
Testosterone |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Immunostaining |
| Description: |
DHT-treated SAMP8 showed a reduction of SA-β-gal-stained endothelial cells and increased SIRT1 expression compared to untreated SAMP8. DHT or testosterone treatment inhibited SA-βgal activity and the morphological appearance of senescence . |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
SIRT1 |
| Target gene experiment: |
Western blot//qRT-PCR |
| Target gene description: |
DHT treatment increased the protein and mRNA expression of SIRT1 in SAMP8 . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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