External factors
| External factors: |
17β-estradiol |
| Category: |
Chemical compounds |
| Phenotype: |
Cardiovascular disease |
| Experiment: |
SA-β-gal activity assay |
| Description: |
The ratio of arterial senescence area was lower in OVX＋E2 mice than in OVX mice .The premature senescence of HUVEC treated with ox-LDL was inhibited by administration of E2. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
SIRT1 |
| Target gene experiment: |
Immunostaining |
| Target gene description: |
Continuous administration of E2 from an E2 pellet increased SIRT1 expression in the endothelial cells of ApoE-KO OVX mice. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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