External factors
| External factors: |
Ginsenoside Rb1 |
| Category: |
Chemical compounds |
| Phenotype: |
Cardiovascular disease |
| Tissue type: |
Umbilical cord,Aorta |
| Experiment: |
SA-β-gal activity assay |
| Description: |
The results suggested that hyperlipidemia induced aortic endothelium senescence and that gRb1 could alleviate it.Results showed that gRb1, but not DMSO, has protective effects on ox-LDL-induced senescence and could alleviate the influence of ox-LDL on autophagy and SIRT1, while gRb1 did not influence senescence, autophagy and SIRT1 of young HUVECs. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
SIRT1 |
| Target gene experiment: |
Western blot |
| Target gene description: |
The western blot results suggested that both low and high dose of gRb1 could alleviate the hyperlipidemia-induced reduction in SIRT1 levels and autophagy inhibition in the aortas. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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