External factors
| External factors: |
Trans-Resveratrol |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
The number of senescence-associated β-galactosidase (SAβgal)-stained cells in a SA-βgal assay increased significantly in the thoracic aortas of STZ-diabetic mice but decreased in the thoracic aortas of the G. gnemon extract-administered mice. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
SIRT1 |
| Target gene experiment: |
Immunofluorescence |
| Target gene description: |
Immunostaining of sections for SIRT1 showed that SIRT1 expression in aortic endothelial cells increased after administration of the extract to STZ-diabetic mice. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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