External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
The old cells and H2O2-treated cells were higher stained with blue color than young cells. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
IGFBP3 |
| Target gene experiment: |
Western blot |
| Target gene description: |
The expression level of IGFBP-3 also remarkably was decreased in H2O2-induced old cells than young cells. |
| Regulatory pathway:
|
p53//PI3K-Akt-mTOR |
| R-EF-Pathway:
|
Activation//-- |
| Official symbol(s): |
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TP53//PI3K-AKT-MTOR
|
| Pathway experiment: |
Western blot |
| Pathway description: |
The expression levels of p300, Ac-p53, p53, p-p21 and p16 also were increased in H2O2-induced old cells higher than young cells. In contrast, the expression levels of SIRT-1,SIRT-6, MDM2 and p-p53 were increased in H2O2-induced old cells in comparison with young cells;The expression level of IGFBP-3 also remarkably was decreased in H2O2-induced old cells than young cells. In contrast, the expression levels of p-PI3K, Akt-1, p-mTOR, p-FoxO1 and FoxO1 were increased in H2O2-induced old cells in comparison with young cells. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.