External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//SAHF |
| Description: |
Treatment with NaHS decreased the percentage of SA-β-gal positive cells.The strongest effect was observed when NaHS was at 50 lmol/L.Treatmentwith NaHS (12.5, 25 and 50 lmol/L) decreased the expression of SAHF the strongest effect was found when NaHS was at 50 lmol/L. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
SIRT1 |
| Target gene experiment: |
Western blot//RT-PCR |
| Target gene description: |
NaHS/resveratrol could increase the expression of SIRT1 compared with Y﹢N group. It was found that the mRNA expression of SIRT1 in Y﹢N group was significantly decreased compared with that in the young group, and NaHS reversed this effect. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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