External factors
| External factors: |
Selaginellin |
| Category: |
Chemical compounds |
| Experiment: |
Telomerase activity assay//SA-β-gal activity assay//Flow cytometry |
| Description: |
Selaginellin concentration dependently inhibited homocysteine-induced cell senescence as shown by the decreased percentages of SA-β-gal–positive cells, the increased telomerase activities, and the decrease in the percentage of cells in the G0/G1phase. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
SIRT1 |
| Target gene experiment: |
qRT-PCR |
| Target gene description: |
In contrast, the decreased mRNA expression of SIRT1 was reversed by pretreatment with selaginellin in a dose-dependent manner. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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