External factors
| External factors: |
Nicotinamide |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//SAHF |
| Description: |
However, in the presence of NAM, the SA-β-gal positive cells’percentage significantly increased in the Y﹢N group compared with that in the young group.The expression of SAHF was significantly increased in Y+N group when compared with that in young cells. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
SIRT1 |
| Target gene experiment: |
Western blot//RT-PCR |
| Target gene description: |
SIRT1 expression in the Y﹢N group was significantly decreased compared with that in young group.The mRNA expression of SIRT1 in Y﹢N group was significantly decreased compared with that in the young group. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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