External factors
| External factors: |
Simvastatin |
| Category: |
Chemical compounds |
| Phenotype: |
Cardiovascular disease |
| Cell name: |
Endothelial cell |
| Experiment: |
SA-β-gal activity assay |
| Description: |
As compared to young rats, the percentage of β-galactosidase-positive cells was significantly increased(22.00% + 2.65% vs 83.67% + 9.50%, P < .001). Administra-tion of simvastatin to aged rats significantly lowered the percentage of β-galactosidase-positive cells as compared to that seen in untreated aged rats (68.83% + 7.47% vs 83.67% + 9.50%, P ? .001). |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
SIRT1 |
| Target gene experiment: |
Western blot |
| Target gene description: |
Pretreatment with simvastatin also significantly inhibited OX-LDL-induced SIRT1 protein downregulation. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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