External factors
| External factors: |
UVB irradiation |
| Experiment: |
SA-β-gal activity assay |
| Description: |
The ratio of senescent cells was markedly greater following UVB irradiation (74.4%) compared with cells that had not been exposed to irradiation (15.7%). |
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Regulatory relationship
| Target gene:
|
MALAT1//MMP1 |
| R-EF-Target gene:
|
Upregulation//Upregulation |
| Official symbol(s): |
MALAT1//MMP1 |
| Target gene experiment: |
RT-PCR//ELISA |
| Target gene description: |
Results further demonstrated that 60 mJ/cm2 UVB increased MALAT1 expression.The results demonstrated that MALAT1 siRNA suppressed MALAT1 expression and inhibited 60 mJ/cm2 UVB-induced MMP-1 secretion . |
| Official symbol(s): |
Warning: Undefined variable $name_all in /data/html/Aging-ReG/public/browse_detail_2.php on line 525
MAPK
|
| Pathway experiment: |
Western blot |
| Pathway description: |
The results demonstrated that 60 mJ/cm2 UVB upregulated ERK, JNK and p38 phosphorylation levels. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.