External factors
| Category: |
Chemical compounds |
| Phenotype: |
Colorectal cancer |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Results from SA-β-gal activity staining indicated that 10 nmol/L FL118 treatment induced approximately 92% of SA-β-gal positivity in the surviving cells . |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Target gene experiment: |
Western blot |
| Target gene description: |
Left plot, FL118 treatment induced expression of human Mdm2 (Hdm2) protein but inhibited expression of human MdmX (HdmX) protein after treatment at 10 nmol/L and 100 nmol/L for 24 hours. |
| Official symbol(s): |
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TP53
|
| Pathway experiment: |
Western blot |
| Pathway description: |
p53 accumulation was induced by as low as 10 nmol/L FL118 treatment in WT p53–bearing HCT116 and HCT8 cells. Time course experiment with HCT8 cells indicated that FL118 induced evident p53 accumulation as short as 4 hours after treatment and reaching a peak after 24-hour treatment and sustained at least for 48 hours . |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.