External factors
| External factors: |
Red wine extract |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Comet assay//Western blot |
| Description: |
Treatment with RWE concentration dependently decreased endothelial senescence by maximally 33+?7.1 %.RWE clearly reduced tBHP-induced DNA damage and p21 protein expression. |
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Regulatory relationship
| Target gene:
|
SIRT1//ENOS//COX-2 |
| R-EF-Target gene:
|
Activation//Upregulation//Upregulation |
| Official symbol(s): |
SIRT1//ENOS//COX2 |
| Target gene experiment: |
qRT-PCR |
| Target gene description: |
RWE increased SIRT1 gene expression (by 14+?10 % at 10 min of exposure, n=8, P<0.05; results not shown).RWE up-regulated eNOS and COX-2 in HUVECs . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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