External factors
| Experiment: |
SA-β-gal activity assay |
| Description: |
In addition, the ratio of senescent cells was significantly lower following intervention with MALAT1 siRNA (52.1%) compared with the UVB irradiation group. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Target gene experiment: |
ELISA |
| Target gene description: |
The results demonstrated that MALAT1 siRNA suppressed MALAT1 expression and inhibited 60 mJ/cm2 UVB-induced MMP-1 secretion . |
| Official symbol(s): |
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MAPK
|
| Pathway experiment: |
Western blot |
| Pathway description: |
The results demonstrated that 60 mJ/cm2 UVB upregulated ERK, JNK and p38 phosphorylation levels, however MALAT1 siRNA inhibited UVB-induced ERK phosphorylation (P<0.01), with no significant influence on JNK and p38 phosphorylation levels. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.