External factors
| External factors: |
Ubiquinol-10 |
| Category: |
Chemical compounds |
| Description: |
For middle (16kHz) and low (8kHz) frequencies, age-associated hearing losses were suppressed by ubiquinol-10 supplementation. |
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Regulatory relationship
| Target gene:
|
SIRT1//PGC-1A//SIRT3 |
| R-EF-Target gene:
|
Upregulation//Upregulation//Upregulation |
| Official symbol(s): |
SIRT1//PGC-1A//SIRT3 |
| Target gene experiment: |
Western blot//qRT-PCR |
| Target gene description: |
We could show that, in agreement with the ABR test and liver results, Sirt3 and Pgc-1a mRNA and protein expression was significantly increased after ubiquinol-10 supplementation. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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