External factors
| External factors: |
Salidroside |
| Category: |
Chemical compounds |
| Cell name: |
Aortic Endothelial cell,Smooth muscle cell,HUVEC |
| Experiment: |
SA-β-gal activity assay//Immunostaining |
| Description: |
When comparing with control group, the cells of aortic endothelium and smooth muscle in mice with chronic HMD treatment showed accelerated up-regulation of p16 INK4A and p21 CIP1. However, SAL treatment abolished these changes in blood vessels. H2O2 induced the upregulation of SA-β-Gal activity, which indicated that the HUVECs were indeed undergoing senescence.SAL treatment at the concentration of 10 uM inhibited the activity of SA-β-Gal. |
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
SIRT3 |
| Target gene experiment: |
Western blot |
| Target gene description: |
B HMD treatment significantly reduced the expression of SIRT3. However, the SAL treatment attenuated the reduced expression of SIRT3. SAL reversed the inhibitory effect of H2O2 on the expression of SIRT3 and endothelial nitric oxide synthase (eNOS). |
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
471
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
472
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 751
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 754
Warning: Undefined variable $pathway_id in /data/html/Aging-ReG/public/browse_detail_2.php on line 793