External factors
| External factors: |
Purple sweet potato color |
| Phenotype: |
Cardiovascular disease |
| Cell name: |
Endothelial cell |
| Experiment: |
Western blot//Cell cycle analysis |
| Description: |
Changes in the p21 level, which was increased by high glucose but decreased by PSPC, confirmed the inhibitory efficiency of PSPC on cellular senescence；We examined the distribution of cell cycle by flowcytometric analysis. In the vehicle control group, high‐glucose‐exposed HUVECs were arrested at the G1 phase of the cell cycleand this arrest was recovered by the addition of PSPC. |
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Regulatory relationship
| Target gene:
|
NLRP3 INFLAMMASOMES |
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
NLRP3 INFLAMMASOMES |
| Target gene experiment: |
Immunofluorescence |
| Target gene description: |
Colocalization of NLRP3 and LC3 was observed in endothelial cells . This phenomenon disappeared in cells treated with glucose or PSPC due to scarce LC3 conversion in the D glucose group or low levels of NLRP3 in D glucose combined PSPC treatment. |
| R-EF-Pathway:
|
Downregulation |
| Official symbol(s): |
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MTOR
|
| Pathway experiment: |
Western blot |
| Pathway description: |
The level of phosphorylated mTOR (p‐mTOR; ser2448) was elevated by high‐glucose administration.However, high glucose failed to increase the phosphorylation of mTOR (ser2448) in the presence of PSPC. No significant difference in p‐mTOR (ser2481) was observed after glucose or PSPC treatment. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.