External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Flow cytometry |
| Description: |
SA-β-gal activity was significantly increased in Ang II and H2O2 stimulated cells in contrast to the control cells (80.63 ± 2.56 and 79.84 ± 3.07% vs. 5.81 ± 0.62%, P\0.01).we used flow cytometry, the cell cycle was arrested at the G0/G1 phase in both Ang II and H2O2-stimulated groups (87.30 ± 2.59 and 82.00 ± 1.66%) as compared to the control group (52.32 ± 2.15, P\0.01). |
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Regulatory relationship
| R-EF-Target gene:
|
Activation |
| Official symbol(s): |
STAT1 |
| Target gene experiment: |
SA-β-gal activity assay//Western blot |
| Target gene description: |
Ang II and H2O2 induced STAT1 activation during HMCs senescence, as manifested by an increase in STAT1 phosphorylation.SA-b-gal-positive cells and the percentage of cells at G0/G1 phase was decreased after STAT1 was knocked down . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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