External factors
| Category: |
Chemical compounds |
| Cell name: |
Human mesangial cell |
| Experiment: |
SA-β-gal activity assay//Flow cytometry//Cell morphological analysis |
| Description: |
SA-β-gal positive cells were significantly increased in Ang II-stimulated cells, in contrast to the control cells (79.79% ± 5.44%; 7.09% ± 2.48%, p < 0.01).Cell morphology was enlarged and flattened after treatment with Ang II. Flow cytometry was used to characterize the nature of cell-cycle arrest. The cell cycle was arrested at the G0/G1 phase in the Ang II-stimulated group (87.98% ±1.83%), compared with the control cells (54.09% ± 1.22%,p < 0.05). |
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Regulatory relationship
| R-EF-Target gene:
|
Activation |
| Official symbol(s): |
STAT1 |
| Target gene experiment: |
Western blot |
| Target gene description: |
Ang II induced STAT1 activation during HMC senescence,as manifested by an increase in STAT1 phosphorylation. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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