External factors
| External factors: |
Losartan |
| Category: |
Chemical compounds |
| Cell name: |
Human mesangial cell |
| Experiment: |
SA-β-gal activity assay//Flow cytometry |
| Description: |
Pretreatment with losartan decreased the percentage of SA-β-gal positive cells, reversed the distribution of cells at each phase. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
STAT1 |
| Target gene experiment: |
Western blot |
| Target gene description: |
Pretreatment with losartan reduced the expression of STAT1, phosphorylation of STAT1, and phosphorylation of p53, p53, and p21Cip1. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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